Krembil Neuroscience Centre (KNC)

Neurovascular Disease - Research

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Milestones and Innovation

Established a multidisciplinary stroke unit/expert team. (1994)
Secondary Stroke Prevention Clinic services launched. (1998)
Ontario Stroke System, MOHLTC Regional Stroke Centre and Secondary Stroke Prevention Clinic designations. (2001)
Major contributor to many of the seminal large multicentre stroke trials that have shaped stroke care including NASCET, PROACT, VISP, AbESTT, CASES, ISAT, FASTER, PRoFESS, CREST, CLOSURE I
One of largest research databases of AVM and Aneurysm Patients
The largest Canadian training centre for interventional neuroradiology
Development of an innovative therapy to counteract brain damage caused by stroke. (2002)
A TWRI team led by Dr. Lyanne Schlichter has developed a new ‘stroke-in-a-dish’ model, allowing scientists to study the events occurring in the penumbra. Their model focuses on microglia, key immune cells that can propagate ongoing toxic reactions in the penumbra, and led to identification of new specific targets, including receptors and secreted factors, which may prove vulnerable to new therapeutics...more

Research

Research and clinical trials are helping us better understand neurovascular conditions and improve stroke prevention and treatment. Our physicians are leading the way in many international stroke-related research projects and conferences; in fact, our techniques attract visiting physicians from around the globe, who come to learn the newest treatments, such as 3D neuroangiography and “stroke busting” techniques.

Basic science research includes investigations into:

Calcium-regulated signaling pathways
Understanding and modulation of the molecular organization of synapses
Anoxic cell damage
Thrombolytic therapy in stroke
Testing neuroprotective strategies in in-vivo models of focal and global cerebral ischemia

Clinical science research includes investigations into:

Clinical trials in drug therapies
Patient registries
Health informatics
Medical education needs and case management needs of patients/families and caregivers

Useful Links

For more information on neurovascular research at the Krembil Neuroscience Centre, visit the Toronto Western Research Institute.

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