Krembil Neuroscience Centre (KNC)

Spine Program - Research

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The Spine Program emphasizes the bench-to-bedside approach that fosters translation of new scientific

Michael G. Fehlings,
MD, PhD, FRCS(C)
Medical Director of the Krembil Neuroscience Program

discovery into improved patient outcomes. Our basic science programs focus on the study of the molecular and cellular basis of Spine cord dysfunction following trauma and innovative treatments to reduce secondary damage and to repair and regenerate the injured Spine cord. Our clinical programs are aimed at advancing patient care and recovery by honing clinical protocols designed to minimize paralysis and permanent damage in persons with acute Spine cord injuries.

Milestones and Innovation

First in Canada to employ image guidance for complex surgery (1995)
Discovered cells that can divide or multiply and migrate, promising the possibility of repair of injury/degeneration of Spine cord (1999)
First in Canada to use minimally invasive kyphoplasty to repair vertebral column fractures (Dr. Michael Fehlings, 2006)
First in Canada to have successfully used adult neural stem cells to regenerate myelin and restore significant mobility in rats (Dr. Michael Fehlings and Dr. Soheila Karimi, 2006)

Research

The Krembil Neuroscience Centre Spine Program is closely linked with the Toronto Western Research Institute and the University of Toronto.

Basic science research includes investigations into:
Basic science research of the Spine Program is aimed at advancing experimental bench-top discoveries through preclinical trials and initiating clinical studies to bring the effects of promising new therapies to benefit individuals with Spine cord injuries. Current investigations include:

Ion channel disturbances
Mitochondrial dysfunction
Death receptor mediated apoptosis
Gene profiling
Endogenous Spine cord stem cells
Stem cell transplantation
Small molecule therapies
Growth factor induced repair and regeneration

Clinical science research:

The Spine Program’s clinical research integrates a multidisciplinary talent pool of dedicated health care providers and neuroscientists. Focus of research includes investigations into

Timing of surgical intervention
Radiographic imaging techniques
Plasticity of neural circuitry after Spine cord injury
Surgical stabilization
Genetic engineering technologies

Funding:

Our vision for providing exemplary clinical care for patients with Spine disorders and Spine cord injury and accomplishing leading “bench-to-bedside” research aimed at discovering a cure for paralysis would not be possible without the support of individuals, corporations, foundations, and provincial and federal agencies. Your help is needed in supporting our Spine Program’s research and education programs.

Useful Links

For more information on Spine research at the Krembil Neuroscience Centre, visit the Toronto Western Research Institute.

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